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In rodents xenobiotics causing peroxisome proliferation induce enzymes of the peroxisomal -oxidation and also the microsomal cytochrome P450 4A family or CYP 4A family (4A1, 4A2, 4A3) involved in the -oxidation of fatty acids (Bell et al, 1992; Muerhoff et al, 1992) Peroxisome proliferator response elements (PPREs) have been reported for rodent cytochrome P450 4A6 and P450 4A1 (Muerhoff et al, 1992; Aldridge et al, 1995; reviewed by Simpson, 1997) Intraperitoneal injection of peroxisome proliferators (the hypolipidemic drugs clo brate or cipro brate) into bluegill (Lepomis macrochirus) and cat sh (Ictalurus punctatus), causes induction of both CYP2M1 and CYP2K1 cytochrome P450 isozymes, known to be associated with lauric acid hydroxylase activity (Haasch, 1996; Haasch et al, 1998) As in mammals, induction was sex-speci c, the protein being more inducible in male bluegill liver and in male cat sh kidney and possibly liver 212. asp.net barcode generator Barcode Generator for ASP . 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Renders ... 3 Peroxisome proliferation Peroxisomes are membrane-bound cytoplasmic organelles appearing in most eukaryotic cells (Hruban & Rechcigl, 1969) Although the enzyme composition of peroxisomes is variable depending on the species, organ or cell type studied, all peroxisomes contain a variety of H2O2 producing oxidases and catalase, which degrades H2O2 (de Duve, 1965; Hruban & Rechcigl, 1969; B ck et al, 1980; Fahimi & Cajaraville, 1995) Apart from their pivotal role in oxyradical metabolism, peroxisomes are involved in several aspects of lipid metabolism These include -oxidation of long chain and very long chain fatty acids, bile acid formation, biosynthesis of ether lipids, biosynthesis of cholesterol and dolichol, and catabolism of prostaglandins and leukotrienes (Reddy & Mannaerts, 1994; Singh, 1997) One of the unique features of peroxisomes is their ability to undergo a massive proliferation, a phenomenon termed peroxisome proliferation which is induced by a number of endogenous compounds and xenobiotics. asp.net barcode generator open source Barcode generation scan free for ASP . 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Peroxisome proliferation consists of an increase in peroxisome number and fractional volume This is usually accompanied by the induction of some peroxisomal enzyme activities, particularly those of the fatty acid -oxidation system (Reddy & Mannaerts, 1994) Acyl-CoA oxidase (AOX), the enzyme catalysing the rst reaction of the -oxidation pathway, the multifunctional enzyme (enoyl-CoA hydratase/3hydroxyacyl-CoA dehydrogenase/isomerase or PH) and thiolase (3-ketoacyl-CoA thiolase. The calculation of the GDOP and various other DOP are then de ned in terms of this H t matrix as a function of time t: A t H t T H t 1 ; p GDOP t tr A t ; q PDOP t A t 1;1 A t 2;2 A t 3;3 ; q HDOP t A t 1;1 A t 2;2 ; q VDOP t A t 3;3 ; q TDOP t A t 4;4 : 7.8.5 Implementation Results 80 Base Technologies effect. The second is the very large wavelength separation between the allocated voice, data, and video channels, which minimizes the amount of Raman interference in adjacent PON channels. As the optical spectrum becomes congested, leading to closer wavelength spacing, interchannel Raman crosstalk could come into play. It is already important as a means of building optical ampli ers because the ampli cation is available at essentially any wavelength [Islam]. It would certainly be a factor in WDM PONs. The ITU speci cations for interchannel separation in such systems are numbers such as 100 GHz (0.8 nm at C-band). In today s PON systems the SRS phenomenon is most likely to cause problems when the power to launch digital data and voice downstream at 1490 nm becomes large enough to induce SRS 60 nm longer at 1550, the wavelength used for analog TV, which is very sensitive to distortion and noise. For modest, unampli ed transmitters at the head end (say up to 2 mW from a laser diode, not an EDFA, as might be the case at 1.25 Gb/s), the degradation in receiver SNR will be less than 0.25 dB [George]. 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